[HTML][HTML] HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase
JP Belzile, G Duisit, N Rougeau, J Mercier… - PLoS …, 2007 - journals.plos.org
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause
G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but
factors directly engaged in this process remain unknown. We used tandem affinity
purification to isolate native Vpr complexes. We found that damaged DNA binding protein 1
(DDB1), viral protein R binding protein (VPRBP), and cullin 4A (CUL4A)—components of a
CUL4A E3 ubiquitin ligase complex, DDB1-CUL4AVPRBP—were able to associate with …
G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but
factors directly engaged in this process remain unknown. We used tandem affinity
purification to isolate native Vpr complexes. We found that damaged DNA binding protein 1
(DDB1), viral protein R binding protein (VPRBP), and cullin 4A (CUL4A)—components of a
CUL4A E3 ubiquitin ligase complex, DDB1-CUL4AVPRBP—were able to associate with …
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